15th Global Experts Meeting on Pathology and Laboratory Medicine
Kursk State Medical University, Russian Federation
Title: Regulatory peptides:the mechanisms of effects on the pain-induced aggressive-defensive behavior
Biography: Lyudmila Severyanova
For many years we have studied the regulatory peptides effects on the integration of nervous, endocrine and immune mechanisms in the pain-induced aggressive-defensive behavior in rats. 23analogues of the natural hypothalamic-pituitary peptides and other peptides synthesized in the Russian Academy of Sciences and "Serva" were administered in intraperitoneal and brain intraventricular injections.With the use of the modified foot-shock model the following regularities of peptide effects were revealed.( i) The key role in peptide effects is played by the L-arginine or L-lysine amino acids residues.In particular ,only the administration of arginine- containing peptides increased pain sensitivity and aggression.(ii) Binding of the tripeptide Pro-Gly -Pro to the amino acid (Arg) or oligopeptide (ACTH 4-7) essentially modifies the influence on the affective aggression. ( iii ) The intensity of aggression depends on the excitability of the brain emotional negative system more than on pain perception.This was demonstrated due to effects of encephalin analogues.( iy ) Peptide effects seemed to be dependent on the brain locus of their primary application. (y) Neuropeptide effects were more expressed in rats with the higher excitability of nociceptive, emotional,opioid and M-cholinergic systems.Since analogues of the natural peptides have been used, there is a reason to believe that obtained data make it possible to elucidate the mechanisms of the development of the pain-induced affective aggression and to develop means for its correction.