Pathology and Laboratory Medicine

Biography

Biography: Lyudmila Severyanova

Abstract

For many years we have studied the regulatory peptides effects on the integration of nervous, endocrine and immune mechanisms in the pain-induced  aggressive-defensive behavior in rats.  23analogues of the natural hypothalamic-pituitary peptides and other peptides  synthesized in the Russian Academy of Sciences and "Serva" were administered in intraperitoneal  and brain intraventricular injections.With the use of the modified  foot-shock model the following regularities of peptide effects were revealed.( i) The key role in peptide effects   is played by the L-arginine or L-lysine amino acids residues.In particular ,only the administration of arginine- containing peptides increased pain sensitivity and aggression.(ii) Binding of the tripeptide Pro-Gly -Pro to the amino acid (Arg) or oligopeptide (ACTH 4-7) essentially modifies the influence on the affective aggression. ( iii ) The intensity of aggression  depends on the excitability of the brain emotional negative system more than on pain perception.This was demonstrated due to effects of encephalin analogues.( iy ) Peptide effects seemed to be dependent on the brain locus of their primary application. (y) Neuropeptide effects were more expressed in rats with the  higher excitability of nociceptive, emotional,opioid and  M-cholinergic systems.Since analogues of  the natural peptides have been used, there is  a reason to believe that obtained data make it possible to elucidate the mechanisms of  the development of the pain-induced affective aggression and to develop means for its correction.